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1

Design and synthesis of pyridine–pyrazolopyridine-based inhibitors of protein kinase B/Akt

Gui-Dong Zhu, Jianchun Gong, Viraj B. Gandhi, Keith Woods, Yan Luo, Xuesong Liu, Ran Guan, Vered Klinghofer, Eric F. Johnson, Vincent S. Stoll, Mulugeta Mamo, Qun Li, Saul H. Rosenberg, Vincent L. Gir

Journal:

Bioorganic & Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 431 KB

english, 2007

2

Synthesis of fluorine-containing aromatic heterocyclic compounds 5. Reactions of 3,5-dinitro-4-chlorobenzotrifluoride and 2-chloro-5-trifluoromethylphenyl isocyanide dichloride with gossypol and apogossypol

Gui-Dong Zhu, De-Hua Chen, Jian-Hua Huang, Fu-Kuang Lui, Ching-Sung Chi

Journal:

Journal of Fluorine Chemistry

Year:

1989

Language:

english

File:

PDF, 373 KB

english, 1989

3

Discovery of the Poly(ADP-ribose) Polymerase (PARP) Inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the Treatment of Cancer

Penning, Thomas D., Zhu, Gui-Dong, Gandhi, Viraj B., Gong, Jianchun, Liu, Xuesong, Shi, Yan, Klinghofer, Vered, Johnson, Eric F., Donawho, Cherrie K., Frost, David J.

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 221 KB

english, 2009

4

Discovery of Inhibitors of Cell Adhesion Molecule Expression in Human Endothelial Cells. 1. Selective Inhibition of ICAM-1 and E-Selectin Expression

Stewart, Andrew O., Bhatia, Pramila A., McCarty, Catherine M., Patel, Meena V., Staeger, Michael A., Arendsen, David L., Gunawardana, Indrani W., Melcher, Laura M., Zhu, Gui-Dong, Boyd, Steven A., Fry

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 354 KB

english, 2001

5

Decreased Intrinsic Functional Connectivity of the Salience Network in Drug-Naïve Patients With Obsessive-Compulsive Disorder

Chen, Yun-Hui, Li, Su-Fang, Lv, Dan, Zhu, Gui-Dong, Wang, Yu-Hua, Meng, Xin, Hu, Qiang, Li, Cheng-Chong, Zhang, Liang-Tang, Chu, Xiang-Ping, Wang, Xiao-Ping, Li, Ping

Journal:

Frontiers in Neuroscience

Year:

2018

Language:

english

File:

PDF, 1.07 MB

english, 2018

6

Intramolecular Diels-Alder Reaction of 8-Trifluoromethyl-1,3,8-Nona-Trienes: An Access to Angular Trifluoromethylated Hydrindenes

Gui-Dong Zhu, Bart Van Lancker, Dirk Van Haver, Pierre J. De Clercq

Journal:

Bulletin des Sociétés Chimiques Belges

Year:

1994

Language:

english

File:

PDF, 933 KB

english, 1994

7

ChemInform Abstract: Diels—Alder Reactions of Hexafluoro-2-butyne with 2-Heterosubstituted Furans: A Facile and General Synthesis of 1,4-Disubstituted 2,3-Di(trifluoromethyl)benzenes.

Gui-Dong Zhu, Michael A. Staeger, Steven A. Boyd

Journal:

Year:

2001

File:

PDF, 33 KB

2001

8

A facile and general synthesis of 2,4-Di- and 2,4,7-trisubstituted thieno[2,3-c]pyridines

Gui-Dong Zhu, Indrani W. Gunawardana, Steven A. Boyd, Laura M. Melcher

Journal:

Journal of Heterocyclic Chemistry

Year:

2008

Language:

english

File:

PDF, 415 KB

english, 2008

9

Discovery and SAR of substituted 3-oxoisoindoline-4-carboxamides as potent inhibitors of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer

Viraj B. Gandhi, Yan Luo, Xuesong Liu, Yan Shi, Vered Klinghofer, Eric F. Johnson, Chang Park, Vincent L. Giranda, Thomas D. Penning, Gui-Dong Zhu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 1.03 MB

english, 2010

10

Synthesis of CD-ring modified 1α,25-dihydroxy vitamin D analogues: C-ring analogues

Gui-Dong Zhu, Yongjun Chen, Xiaoming Zhou, Maurits Vandewalle, Pierre J. De Clercq, R. Bouillon, A. Verstuyf

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 317 KB

english, 1996

11

Synthesis and SAR of indazole-pyridine based protein kinase B/Akt inhibitors

Keith W. Woods, John P. Fischer, Akiyo Claiborne, Tongmei Li, Sheela A. Thomas, Gui-Dong Zhu, Robert B. Diebold, Xuesong Liu, Yan Shi, Vered Klinghofer, Edward K. Han, Ran Guan, Shayna R. Magnone, Eri

Journal:

Bioorganic & Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 266 KB

english, 2006

12

Discovery and SAR of 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer

Thomas D. Penning, Gui-Dong Zhu, Viraj B. Gandhi, Jianchun Gong, Sheela Thomas, Wilfried Lubisch, Roland Grandel, Wolfgang Wernet, Chang H. Park, Elizabeth H. Fry, Xuesong Liu, Yan Shi, Vered Klinghof

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 384 KB

english, 2008

13

Synthesis and structure–activity relationship of 3,4′-bispyridinylethylenes: Discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer

Qun Li, Keith W. Woods, Sheela Thomas, Gui-Dong Zhu, Garrick Packard, John Fisher, Tongmei Li, Jianchun Gong, Jurgen Dinges, Xiaohong Song, Jason Abrams, Yan Luo, Eric F. Johnson, Yan Shi, Xuesong Liu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 463 KB

english, 2006

14

Synthesis and SAR of novel, potent and orally bioavailable benzimidazole inhibitors of poly(ADP-ribose) polymerase (PARP) with a quaternary methylene-amino substituent

Gui-Dong Zhu, Viraj B. Gandhi, Jianchun Gong, Sheela Thomas, Yan Luo, Xuesong Liu, Yan Shi, Vered Klinghofer, Eric F. Johnson, David Frost, Cherrie Donawho, Ken Jarvis, Jennifer Bouska, Kennan C. Mars

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 208 KB

english, 2008

15

Studies on fluorine-containing aromatic heterocyclic compounds 4. Reactions of 3-trifluoromethylphenyl- and 2-chloro-5-trifluoromethylphenyl isocyanide dichlorides with bifunctional nucleophiles

Gui-Dong Zhu, Jian-Hua Huang, Ching-Sung Chi

Journal:

Journal of Fluorine Chemistry

Year:

1989

Language:

english

File:

PDF, 449 KB

english, 1989

16

11-fluoro-1α-hydroxyvitamin D3: The quest for experimental evidence of the folded vitamin D conformation

Gui-Dong Zhu, Dirk Van Haver, Hans Jurriaans, Pierre J. De Clercq

Journal:

Year:

1994

Language:

english

File:

PDF, 800 KB

english, 1994

17

Discovery of trans-3,4′-bispyridinylethylenes as potent and novel inhibitors of protein kinase B (PKB/Akt) for the treatment of cancer: Synthesis and biological evaluation

Qun Li, Tongmei Li, Gui-Dong Zhu, Jianchun Gong, Akiyo Claibone, Chris Dalton, Yan Luo, Eric F. Johnson, Yan Shi, Xuesong Liu, Vered Klinghofer, Joy L. Bauch, Kennan C. Marsh, Jennifer J. Bouska, Shan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 429 KB

english, 2006

18

Isoquinoline–pyridine-based protein kinase B/Akt antagonists: SAR and in vivo antitumor activity

Gui-Dong Zhu, Jianchun Gong, Akiyo Claiborne, Keith W. Woods, Viraj B. Gandhi, Sheela Thomas, Yan Luo, Xuesong Liu, Yan Shi, Ran Guan, Shayna R. Magnone, Vered Klinghofer, Eric F. Johnson, Jennifer Bo

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 175 KB

english, 2006

19

Discovery and SAR of oxindole–pyridine-based protein kinase B/Akt inhibitors for treating cancers

Gui-Dong Zhu, Viraj B. Gandhi, Jianchun Gong, Yan Luo, Xuesong Liu, Yan Shi, Ran Guan, Shayna R. Magnone, Vered Klinghofer, Eric F. Johnson, Jennifer Bouska, Alexander Shoemaker, Anatol Oleksijew, Ken

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 185 KB

english, 2006

20

Biological Activity of CD-Ring Modified 1α,25-Dihydroxyvitamin D Analogues: C-Ring and Five-Membered D-Ring Analogues

Annemieke Verstuyf, Lieve Verlinden, Evelyne Van Etten, Ling Shi, Yusheng Wu, Chris D'Halleweyn, Dirk Van Haver, Gui-Dong Zhu, Yong-Jun Chen, Xiaoming Zhou, Mark R. Haussler, Pierre De Clercq, Maurits

Journal:

Journal of Bone and Mineral Research

Year:

2000

Language:

english

File:

PDF, 2.37 MB

english, 2000

21

Syntheses of Potent, Selective, and Orally Bioavailable Indazole-Pyridine Series of Protein Kinase B/Akt Inhibitors with Reduced Hypotension

Zhu, Gui-Dong, Gandhi, Viraj B., Gong, Jianchun, Thomas, Sheela, Woods, Keith W., Song, Xiaohong, Li, Tongmei, Diebold, R. Bruce, Luo, Yan, Liu, Xuesong

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 344 KB

english, 2007

22

The crystal structure of a new gossypol derivative: — 8,8′-Dibromo-6,6′,7,7′-tetramethoxy-5,5′-diisopropyl-3,3′- oxydimethylene dinaphtho[2,1-b:2′,1′-d]furan

Zhu Gui-Dong, Chen De-Hua, Huang Jian-Hua, Chi Ching-Sung, Dong Jun, Chen Min-Qin, Zheng Pei-Ju

Journal:

Chinese Journal of Chemistry

Year:

1990

Language:

english

File:

PDF, 259 KB

english, 1990

23

Discovery and SAR of orally efficacious tetrahydropyridopyridazinone PARP inhibitors for the treatment of cancer

Gui-Dong Zhu, Jianchun Gong, Viraj B. Gandhi, Xuesong Liu, Yan Shi, Eric F. Johnson, Cherrie K. Donawho, Paul A Ellis, Jennifer J. Bouska, Donald J. Osterling, Amanda M. Olson, Chang Park, Yan Luo, Al

Journal:

Bioorganic & Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 1.40 MB

english, 2012

24

Conformationally restricted mimics of vitamin D rotamers

William H. Okamura, Steven Do, Hoim Kim, S. Jeganathan, Thong Vu, Gui-Dong Zhu, Anthony W. Norman

Journal:

Year:

2001

Language:

english

File:

PDF, 690 KB

english, 2001

25

Optimization of Phenyl-Substituted Benzimidazole Carboxamide Poly(ADP-Ribose) Polymerase Inhibitors: Identification of ( S )-2-(2-Fluoro-4-(pyrrolidin-2-yl)phenyl)-1 H -benzimidazole-4-carboxamide (A-966492), a Highly Potent and Efficacious Inhibitor

Penning, Thomas D., Zhu, Gui-Dong, Gong, Jianchun, Thomas, Sheela, Gandhi, Viraj B., Liu, Xuesong, Shi, Yan, Klinghofer, Vered, Johnson, Eric F., Park, Chang H., Fry, Elizabeth H., Donawho, Cherrie K.

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 2.92 MB

english, 2010

26

Synthesis of Vitamin D (Calciferol)

Zhu, Gui-Dong., Okamura, William H.

Journal:

Chemical Reviews

Year:

1995

Language:

english

File:

PDF, 9.04 MB

english, 1995

27

Synthesis and NMR Studies of 13 C-Labeled Vitamin D Metabolites 1

Okamura, William H., Zhu, Gui-Dong, Hill, David K., Thomas, Richard J., Ringe, Kerstin, Borchardt, Daniel B., Norman, Anthony W., Mueller, Leonard J.

Journal:

Journal of Organic Chemistry

Year:

2002

Language:

english

File:

PDF, 199 KB

english, 2002

28

Selective Inhibition of ICAM-1 and E-Selectin Expression in Human Endothelial Cells. 2. Aryl Modifications of 4-(Aryloxy)thieno[2,3- c ]pyridines with Fine-Tuning at C-2 Carbamides

Zhu, Gui-Dong, Arendsen, David L., Gunawardana, Indrani W., Boyd, Steven A., Stewart, Andrew O., Fry, Dennis G., Cool, Barbara L., Kifle, Lemma, Schaefer, Verlyn, Meuth, Joseph, Marsh, Kennan C., Kemp

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 330 KB

english, 2001

29

VP22 enhances the expression of glucocerebrosidase in human Gaucher II fibroblast cells mediated by lentiviral vectors

Gui-shan Jin,Gui-dong Zhu,Zhi-gang Zhao…

Journal:

Clinical and Experimental Medicine

Year:

2012

Language:

english

File:

PDF, 415 KB

english, 2012

30

Synthesis, Biological Activity, and Conformational Analysis of Four seco - d -15,19- bisnor -1α,25-Dihydroxyvitamin D Analogues, Diastereomeric at C17 and C20

Zhou, Xiaoming, Zhu, Gui-Dong, Van Haver, Dirk, Vandewalle, Maurits, De Clercq, Pierre J., Verstuyf, Annemieke, Bouillon, Roger

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 496 KB

english, 1999

31

Synthesis and Mode of Action of 125 I- and 3 H-Labeled Thieno[2,3- c ]pyridine Antagonists of Cell Adhesion Molecule Expression

Zhu, Gui-Dong, Schaefer, Verlyn, Boyd, Steven A., Okasinski, Gregory F.

Journal:

Journal of Organic Chemistry

Year:

2002

Language:

english

File:

PDF, 77 KB

english, 2002

32

Diels−Alder Reactions of Hexafluoro-2-butyne with 2-Heterosubstituted Furans: A Facile and General Synthesis of 1,4-Disubstituted 2,3-Di(trifluoromethyl)benzenes

Zhu, Gui-Dong, Staeger, Michael A., Boyd, Steven A.

Journal:

Organic Letters

Year:

2000

Language:

english

File:

PDF, 54 KB

english, 2000

33

Poly (ADP-ribose) polymerase activity regulates apoptosis in HeLa cells after alkylating DNA damage

Liu, Xuesong, Luo, Xu, Yan Shi, Yan, Zhu, Gui-dong, Penning, Thomas, Giranda, Vincent L, Luo, Yan

Journal:

Cancer Biology & Therapy

Year:

2008

Language:

english

File:

PDF, 1.08 MB

english, 2008

34

Scandium-Mediated Opening of Aziridine Carboxylates: A Facile Synthesis of Aryl Substituted Tryptophans

Bennani, Youssef L., Zhu, Gui-Dong, Freeman, Jennifer C.

Journal:

Year:

1998

Language:

english

File:

PDF, 40 KB

english, 1998

35

Targeting Serine / Threonine Protein Kinase B / Akt and Cell-cycle Checkpoint Kinases for Treating Cancer

Li, Qun, Zhu, Gui-Dong

Journal:

Current Topics in Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 519 KB

english, 2002

36

Effective and long-term outcome following ligation of the intersphincteric fistula tract (LIFT) for transsphincteric fistula

Chen, Hong-Jin, Sun, Gui-Dong, Zhu, Ping, Zhou, Zai-Long, Chen, Yu-Gen, Yang, Bo-Lin

Journal:

International Journal of Colorectal Disease

Year:

2017

Language:

english

File:

PDF, 238 KB

english, 2017

37

Chemical constituents of Viscum coloratum (Kom.) Nakai and their cytotoxic activities

Chen, Ying-Ying, Hou, Jiang-Ping, Huang, Ling, Khan, Afsar, Xing, Fei-Fei, Zhang, Xiao-Han, Han, De-Feng, Yan, Shi-Li, Cao, Gui-Dong, Jiao, Qi-Yang, Liu, Dejie, Zhu, Xuwei, Hu, Qingwen, Lou, Hong-Xian

Journal:

Natural Product Research

Year:

2020

File:

PDF, 1016 KB

2020